New meningitis vaccine hailed as major step

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A successful test of a meningitis vaccination n Africa has raised hopes for its eventual eradication as the disease currently claims the lives of 250,000 people annually.

The five main meningococcal strains found in Africa, including the newly emerging X strain, for which there is currently no legal injectable, will be protected by the NmCV-5 vaccine, which was created by the Serum Institute of India and the global health organization Path.

According to a paper released on Wednesday in the New England Journal of Medicine, vaccine trials were carried out in 2021 among 1,800 individuals between the ages of two and 29 in Mali and the Gambia. The study team discovered that NmCV-5 produced a potent immune response against each of the five pathogens.

Bacterial or viral infections that irritate the membranes enclosing the brain and spinal cord can result in meningitis. At least 60% of fatalities take place in Africa, mainly along the “meningitis belt,” which runs from Ethiopia in the east to the Gambia and Senegal in the west.

According to studies, late diagnosis and treatment are among the reasons why people in Africa are twice as likely as persons in high-income nations to experience severe long-term effects from the disease.

Most African nations need tens of millions of doses of the four meningitis vaccines that are currently available, but their price is currently too costly. Meningococcal A cases were significantly reduced by the MenAfriVac, which was introduced in 2010, but large-scale outbreaks connected to the other strains are frequent in Africa.=

NmCV-5 to combat Meningitis will be available in the coming months

According to researchers developing the new vaccine from the Medical Research Council Unit the Gambia at the London School of Hygiene & Tropical Medicine and the Centre for Vaccine Development in Mali, protection against the X strain is especially crucial because it has the potential to spread quickly and there are currently no vaccines to prevent or control it.

Co-author of the paper Ed Clarke expressed excitement about the findings. We anticipate that NmCV-5 will offer children and adolescents trustworthy defense against meningitis brought on by the meningococcal bacteria in Africa.

He continued, “It should be gamechanging for controlling epidemic meningitis in the’meningitis belt’.” “We anticipate the vaccine being introduced to the area as soon as possible.”

By 2030, the World Health Organization hopes to cut meningitis mortality and vaccine-preventable meningitis by 50% and 70%, respectively.

“Epidemic preparedness is the way forward in providing available, affordable, and accessible vaccines relevant to regions prone to meningitis outbreaks,” said Ama Umesi, another co-author.Meningitis vaccines should be a top public health priority because they would revolutionize the fight against the disease and avert catastrophic results during an outbreak.

“Avoid catastrophic results”

Epidemic preparedness is the way to go in terms of making vaccines relevant to areas prone to meningitis epidemics available, affordable, and accessible. “Having meningitis vaccines would be a game changer in the fight against meningitis and should be a public health priority to prevent catastrophic outcomes during an outbreak,” said study co-author Ama Umesi.

According to the WHO, the most common type of meningitis is caused by bacteria and cannot be treated at home because it can be fatal within 24 hours. Although it is widespread, sub-Saharan Africa has some of the highest rates of instances.

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In 2030, the WHO’s Defeating Meningitis by 2030 road map seeks to eradicate bacterial meningitis outbreaks, cut back on “vaccine-preventable bacterial meningitis” by 50%, and reduce mortality by 70%.